1: J Control Release. 2007 Jul 16;120(1-2):79-87. Epub 2007 Mar 31.

Passive diffusion of polymeric surfactants across lipid bilayers.

Mathot F, Schanck A, Van Bambeke F, AriŽn A, Noppe M, Brewster M, Pr√©at V.

Université Catholique de Louvain, Unité de Pharmacie Galénique, UCL, Brussels,
Belgium.

Self-assembling polymeric surfactant, mmePEG(750)P(CL-co-TMC) [monomethylether
poly(ethylene glycol)(750)-poly(caprolactone-co-trimethylene carbonate)],
increases drug solubility and crosses an enterocyte monolayer both in vitro and
in vivo. The aims of the present work were to investigate whether
mmePEG(750)P(CL-co-TMC) polymers can diffuse passively through lipid bilayer
using parallel artificial membrane permeability assay (PAMPA) and affect membrane
properties using liposomes as model. The mmePEG(750)P(CL-co-TMC) polymer was able
to cross by passive diffusion an enterocyte-mimicking membrane in PAMPA at
concentration which did not perturb membrane integrity. A weak rigidification
associated with a low increase in permeability of liposomal lipid bilayers was
observed. These data suggest that polymeric surfactants can cross the lipid
membrane by passive diffusion and interact with lipid bilayers.

Publication Types: 
    Research Support, Non-U.S. Gov't

PMID: 17524515 [PubMed - indexed for MEDLINE]

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