1: J Control Release. 2007 Jul 16;120(1-2):79-87. Epub 2007 Mar 31.

Passive diffusion of polymeric surfactants across lipid bilayers.

Mathot F, Schanck A, Van Bambeke F, Ariën A, Noppe M, Brewster M, Préat V.

Université Catholique de Louvain, Unité de Pharmacie Galénique, UCL, Brussels,
Belgium.

Self-assembling polymeric surfactant, mmePEG(750)P(CL-co-TMC) [monomethylether
poly(ethylene glycol)(750)-poly(caprolactone-co-trimethylene carbonate)],
increases drug solubility and crosses an enterocyte monolayer both in vitro and
in vivo. The aims of the present work were to investigate whether
mmePEG(750)P(CL-co-TMC) polymers can diffuse passively through lipid bilayer
using parallel artificial membrane permeability assay (PAMPA) and affect membrane
properties using liposomes as model. The mmePEG(750)P(CL-co-TMC) polymer was able
to cross by passive diffusion an enterocyte-mimicking membrane in PAMPA at
concentration which did not perturb membrane integrity. A weak rigidification
associated with a low increase in permeability of liposomal lipid bilayers was
observed. These data suggest that polymeric surfactants can cross the lipid
membrane by passive diffusion and interact with lipid bilayers.

Publication Types: 
    Research Support, Non-U.S. Gov't

PMID: 17524515 [PubMed - indexed for MEDLINE]

Related Links

    Encapsulation of amphotericin B in poly(ethylene
glycol)-block-poly(epsilon-caprolactone-co-trimethylenecarbonate) polymeric
micelles. [Int J Pharm. 2006] PMID:16406402

    Mixed micelles and other structures in the solubilization of bilayer lipid
membranes by surfactants. [Biochim Biophys Acta. 2000] PMID:11090823

    Tethered polymer-supported planar lipid bilayers for reconstitution of integral
membrane proteins: silane-polyethyleneglycol-lipid as a cushion and covalent
linker. [Biophys J. 2000] PMID:10969002

    Effects of nonionic surfactants on membrane transporters in Caco-2 cell
monolayers. [Eur J Pharm Sci. 2002] PMID:12208453

    The polymer-supported phospholipid bilayer: tethering as a new approach to
substrate-membrane stabilization. [Biomacromolecules. 2002] PMID:11866552