1: J Cyst Fibros. 2008 Nov;7(6):551-4. Epub 2008 Aug 15.

Temocillin in cystic fibrosis: A retrospective pilot study.

Kent L, Bradley JM, France M, Döring G, Carryn S, Bradbury I, Rendall J, Jones A,
Elborn JS.

Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland, United
Kingdom; University of Ulster, Shore Road, Newtownabbey, BT37 OQB, Northern
Ireland, United Kingdom.

BACKGROUND: Temocillin is currently used in the treatment of acute pulmonary
exacerbations caused by Burkholderia cepacia complex and multi-resistant
Pseudomonas aeruginosa in cystic fibrosis (CF) patients despite little published 
clinical data. This study assessed if intravenous (IV) antibiotic therapy
including temocillin was equivalent to standard combination therapy for an acute 
exacerbation. METHODS: A retrospective, pilot cross-over study. Adult patients
attending two CF centres between 1997 and 2006 who had received a course of IV
antibiotics including temocillin (TIV) and a further IV course (within +/-1 year)
which did not include temocillin (NTIV) were included. Outcome measures at the
start and end of each IV course were recorded (FEV(1)%, FVC%). RESULTS: Twenty
six patients had received temocillin. Baseline values of FEV(1)% predicted were
comparable for both groups (TIV: 37(18%), NTIV: 39(20%)). FEV(1)% increased by
7.12(11.67)% after TIV (p<0.01) and 6.65(7.62)% after NTIV (p<0.01). There was no
significant difference between the IV courses in mean %change in lung function
TIV versus NTIV (FEV(1) 0.46% [95%CI: -4.55 to 5.48%]). CONCLUSION: These data
suggest equivalence in the lung function outcome of IV antibiotic therapy
includingtemocillin versus standard IV antibiotic therapy.


PMID: 18706868 [PubMed - in process]

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