1: J Cyst Fibros. 2008 Nov;7(6):551-4. Epub 2008 Aug 15.

Temocillin in cystic fibrosis: A retrospective pilot study.

Kent L, Bradley JM, France M, Döring G, Carryn S, Bradbury I, Rendall J, Jones A,
Elborn JS.

Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland, United
Kingdom; University of Ulster, Shore Road, Newtownabbey, BT37 OQB, Northern
Ireland, United Kingdom.

BACKGROUND: Temocillin is currently used in the treatment of acute pulmonary
exacerbations caused by Burkholderia cepacia complex and multi-resistant
Pseudomonas aeruginosa in cystic fibrosis (CF) patients despite little published 
clinical data. This study assessed if intravenous (IV) antibiotic therapy
including temocillin was equivalent to standard combination therapy for an acute 
exacerbation. METHODS: A retrospective, pilot cross-over study. Adult patients
attending two CF centres between 1997 and 2006 who had received a course of IV
antibiotics including temocillin (TIV) and a further IV course (within +/-1 year)
which did not include temocillin (NTIV) were included. Outcome measures at the
start and end of each IV course were recorded (FEV(1)%, FVC%). RESULTS: Twenty
six patients had received temocillin. Baseline values of FEV(1)% predicted were
comparable for both groups (TIV: 37(18%), NTIV: 39(20%)). FEV(1)% increased by
7.12(11.67)% after TIV (p<0.01) and 6.65(7.62)% after NTIV (p<0.01). There was no
significant difference between the IV courses in mean %change in lung function
TIV versus NTIV (FEV(1) 0.46% [95%CI: -4.55 to 5.48%]). CONCLUSION: These data
suggest equivalence in the lung function outcome of IV antibiotic therapy
includingtemocillin versus standard IV antibiotic therapy.

PMID: 18706868 [PubMed - in process]

Related Links

    Temocillin in the treatment of Burkholderia cepacia infection in cystic fibrosis.
[J Cyst Fibros. 2006] PMID:16650744

    Temocillin and cystic fibrosis: outcome of intravenous administration in patients
infected with Pseudomonas cepacia. [J Antimicrob Chemother. 1992] PMID:1375595

    Long term clinical outcome of home and hospital intravenous antibiotic treatment 
in adults with cystic fibrosis. [Thorax. 2004] PMID:14985563

    Efficacy of once-daily tobramycin monotherapy for acute pulmonary exacerbations
of cystic fibrosis: a preliminary study. [Pediatr Pulmonol. 2001] PMID:11340683

    The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin
in the treatment of acute pulmonary exacerbations in patients with cystic
fibrosis. [Chest. 2005] PMID:16236892