1: Antimicrob Agents Chemother. 2008 Apr 7. [Epub ahead of print]
(2008) 52:2236–2238

Apoptosis induced by aminoglycosides in LLC-PK1 cells: comparison between
neomycin, gentamicin, amikacin, and isepamicin using electroporation.

Denamur S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM.

Unité de Pharmacologie cellulaire et moléculaire, Université catholique de
Louvain, B-1200 Brussels, Belgium.

Aminoglycosides were compared for apoptosis induction (DAPI staining, activation 
of caspase 3) in renal LLC-PK1 cells. Amikacin caused less apoptosis than
gentamicin in incubated cells. In electroporated cells, neomycin B and gentamicin
caused apoptosis in the 0.06-0.1 mM range, isepamicin required larger
concentrations (0.2 mM), and amikacin was without effect.

PMID: 18391041 [PubMed - as supplied by publisher]

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