1. Eur J Med Chem. 2013 Apr 9;64C:357-364. doi: 10.1016/j.ejmech.2013.03.064. [Epub 
ahead of print]

2-Aminobenzothiazole derivatives: Search for new antifungal agents.

Catalano A, Carocci A, Defrenza I, Muraglia M, Carrieri A, Van Bambeke F, Rosato 
A, Corbo F, Franchini C.

Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari
"Aldo Moro", via E. Orabona n. 4, 70125 Bari, Italy.

A new series of 6-substituted 2-aminobenzothiazole derivatives were synthesized
and screened in vitro as potential antimicrobials. Almost all the compounds
showed antifungal activity. In particular, compounds 1n,o, designed on the basis 
of molecular modeling studies, were the best of the series, showing MIC values of
4-8 μg/mL against Candida albicans, Candidaparapsilosis and Candidatropicalis.
None of the two compounds did show any cytotoxicity effect on human THP-1 cells.

Copyright © 2013 Elsevier Masson SAS. All rights reserved.

PMID: 23644218  [PubMed - as supplied by publisher]